Io Rune
An Io Rune is a low tier rune that can be socketed into armor and weapons in Diablo2: Lord of Destruction and Diablo 2 Resurrected.
An Io Rune requires level 35 to use. When you socket an item with an Io Rune, you increase the level requirement to level 35, unless it was already higher.
| Mods | |
| Weapon | +10 to Vitality |
| Armor | +10 to Vitality |
| Shield | +10 to Vitality |
| Sources | |
| Countess | Nightmare and above |
| Hellforge | Nightmare |
| Treasure Class | Act 1 (N) Good |
| Cube | 3 Hel Rune + Chipped Diamond |
| Runewords | |
| Original | |
| 1.10 | |
| 2.4 | |
| 2.6 | |
| 3.0 | |
| Cube Recipes | |
| Other | Lum RuneIncendiary Flame Rift |
| Prev/Next | |
Effects
- Weapon: +10 to Vitality
- Armor: +10 to Vitality
- Shield: +10 to Vitality
An Io Rune requires level 35 to use. When you socket an item with an Io Rune, you increase the level requirement to level 35, unless it was already higher.
How to get Io Runes
- The Countess on Nightmare difficulty and above has a chance to drop Io Runes
- The Hellforge on Nightmare difficulty has a 1/11 chance to drop a Io Rune as quest reward
- The Act 1 (N) Good and higher Treasure Classes can drop Io Runes
- Transmute 3
Hel Runes and a Chipped Diamond in the Horadric Cube
Runewords
An Io Rune Rune is used in the following Runewords:
- Original
- 1.10
- 2.4
- Obsession: zod + ist + lem + lum + io + nef in Staff
- Unbending Will: fal + io + ith + eld + el + hel in Sword
- 2.6
- 3.0
- Coven: ist + ral + io in Helm
Horadric Cube Recipes with Io Rune Runes
Drop Chance
An Io Rune will drop from TC Runes 8, which is accessed through Runes 9, Act 1 (N) Good or Countess Rune (N). Learn more about Treasure Classes here.




