io rune

An Io rune is a low tier rune that can be socketed into armor and weapons in Diablo 2: Lord of Destruction and Diablo 2 Resurrected. An Io rune provides +10 to Vitality when inserted in any item.

You can cube 3 Hel runes and a chipped diamond together to get an Io rune. You can also obtain an Io rune from nightmare countess. You can get an Io rune from the nightmare hellforge quest.

An Io rune requires level 35 to use. When you socket an item with an Io rune, you increase the level requirement to level 35, unless it was already higher.

Clvl 35
weapon+10 to Vitalityarmor/helm+10 to Vitalityshield+10 to Vitality
rune sources

Countess:

nightmare and above

Hellforge:

nightmare

Treasure class:

act 1 (nm) good and above

Cube:

3 hel + chipped diamond

Horadric cube recipes with io runes

3x
io runeio rune
+
flawed topazflawed topaz
lum runelum rune

    There are 8 runewords that contain an io rune

    list of all runewords in Diablo 2 made with an io rune
    Runeword
    Sockets
    Allowed BasesRuneword Recipe
    Level
    Stats
    Black3 socketsclubhammermace
    thul + io + nef
    35
    +15% Increased Attack Speed+120% Enhanced Damage+200 to Attack RatingAdds 3-14 Cold Damage (thul)40% Chance of Crushing BlowKnockback (nef)+10 to Vitality (io)Magic Damage Reduced By 2Level 4 Corpse Explosion (12 Charges)
    White2 socketswand
    dol + io
    35
    +3 to Poison and Bone Skills (Necromancer Only)+20% Faster Cast Rate+2 to Bone Spear (Necromancer Only)+4 to Skeleton Mastery (Necromancer Only)+3 to Bone Armor (Necromancer Only)Hit causes monster to flee 25% (dol)+10 to vitality (io)+13 to manaMagic Damage Reduced by 4
    Memory4 socketsstaff
    lum + io + sol + eth
    37
    +3 To Sorceress Skill Levels+33% Faster Cast Rate+9 To Minimum Damage (sol)-25% Target Defense (eth)+3 To Energy Shield (Sorceress Only)+2 To Static Field (Sorceress Only)+50% Enhanced Defense+10 to Vitality (io)+10 to Energy (lum)Increase Maximum Mana 20%Magic Damage Reduced By 7
    Unbending Will6 socketssword
    fal + io + ith + eld + el + hel
    41
    18% Chance To Cast Level 18 Taunt On Striking+3 to Combat Skills (Barbarian Only)+20-30% Increased Attack Speed (varies)+300-350% Enhanced Damage+9 to Maximum Damage (ith)+50 to Attack Rating (el)+75 Damage to Undead+50 to Attack Rating Against Undead (eld)8-10% Life Stolen Per Hit (varies)Prevent Monster Heal+10 to Strength (fal)+10 to Vitality (io)Damage Reduced By 8+1 to Light Radius (el)Requirements -20% (hel)
    Delirium3 socketshelm
    lem + ist + io
    51
    1% Chance To Cast level 50 Delirium When Struck6% Chance To Cast level 14 Mind Blast When Struck14% Chance To Cast level 13 Terror When Struck11% Chance To Cast level 18 Confuse On Striking+2 To All Skills+261 Defense+10 To Vitality (io)50% Extra Gold From Monsters (lem)25% Better Chance of Getting Magic Items (ist)Level 17 Attract (60 Charges)
    Dream3 socketshelmshield
    io + jah + pul
    65
    10% Chance To Cast Level 15 Confuse When StruckLevel 15 Holy Shock Aura When Equipped+20-30% Faster Hit Recovery (varies)+30% Enhanced Defense (pul)+150-220 Defense (varies)+10 To Vitality (io)+(0.625*Clvl) To Mana (Based On Character Level)All Resistances +5-20 (varies)12-25% Better Chance of Getting Magic Items (varies)HeadgearIncrease Maximum Life 5% (jah)Shields+50 To Life (jah)
    Pride4 socketspolearmspear
    cham + sur + io + lo
    67
    25% Chance To Cast Level 17 Fire Wall When StruckLevel 16-20 Concentration Aura When Equipped (varies)260-300% Bonus To Attack Rating (varies)+(1*Clvl)% Damage To Demons (Based on Character Level)Adds 50-280 Lightning Damage20% Deadly Strike (lo)Hit Blinds Target (sur)Freezes Target +3 (cham)+10 To Vitality (io)Replenish Life +8(1.875*Clvl)% Extra Gold From Monsters (Based on Character Level)
    Obsession6 socketsstaff
    zod + ist + lem + lum + io + nef
    69
    Indestructible (zod)24% Chance to cast level 10 Weaken when struck+4 To All Skills+65% Faster Cast Rate+60% Faster Hit RecoveryKnockback (nef)+10 To Vitality (io)+10 To Energy (lum)Increase Maximum Life 15-25% (varies)Regenerate Mana 15-30% (varies)All Resistances +60-70 (varies)75% Extra Gold from Monsters (lem)30% Better Chance of Getting Magic Items (ist)