An Io rune is a low tier rune that can be socketed into armor and weapons in Diablo 2: Lord of Destruction and Diablo 2 Resurrected. An Io rune provides +10 to Vitality when inserted in any item.
You can cube 3 Hel runes and a chipped diamond together to get an Io rune. You can also obtain an Io rune from nightmare countess. You can get an Io rune from the nightmare hellforge quest.
An Io rune requires level 35 to use. When you socket an item with an Io rune, you increase the level requirement to level 35, unless it was already higher.
Horadric cube recipes with io runes
An Io rune will drop from TC Runes 8, which is accessed through Runes 9, Act 1 (N) Good or Countess Rune (N). Learn more about Treasure Classes here.
Act 1 (N) Good
There are 8 runewords that contain an io rune
|Allowed Bases||Runeword Recipe|
|Black||3 sockets||club, hammer, mace||35|
|Unbending Will||6 sockets||sword||41|
18% Chance To Cast Level 18 Taunt On Striking+3 to Combat Skills (Barbarian Only)+20-30% Increased Attack Speed (varies)+300-350% Enhanced Damage+9 to Maximum Damage (ith)+50 to Attack Rating (el)+75 Damage to Undead+50 to Attack Rating Against Undead (eld)8-10% Life Stolen Per Hit (varies)Prevent Monster Heal+10 to Strength (fal)+10 to Vitality (io)Damage Reduced By 8+1 to Light Radius (el)Requirements -20% (hel)
1% Chance To Cast level 50 Delirium When Struck6% Chance To Cast level 14 Mind Blast When Struck14% Chance To Cast level 13 Terror When Struck11% Chance To Cast level 18 Confuse On Striking+2 To All Skills+261 Defense+10 To Vitality (io)50% Extra Gold From Monsters (lem)25% Better Chance of Getting Magic Items (ist)Level 17 Attract (60 Charges)
|Dream||3 sockets||helm, shield||65|
10% Chance To Cast Level 15 Confuse When StruckLevel 15 Holy Shock Aura When Equipped+20-30% Faster Hit Recovery (varies)+30% Enhanced Defense (pul)+150-220 Defense (varies)+10 To Vitality (io)+(0.625*Clvl) To Mana (Based On Character Level)All Resistances +5-20 (varies)12-25% Better Chance of Getting Magic Items (varies)HeadgearIncrease Maximum Life 5% (jah)Shields+50 To Life (jah)
|Pride||4 sockets||polearm, spear||67|
25% Chance To Cast Level 17 Fire Wall When StruckLevel 16-20 Concentration Aura When Equipped (varies)260-300% Bonus To Attack Rating (varies)+(1*Clvl)% Damage To Demons (Based on Character Level)Adds 50-280 Lightning Damage20% Deadly Strike (lo)Hit Blinds Target (sur)Freezes Target +3 (cham)+10 To Vitality (io)Replenish Life +8(1.875*Clvl)% Extra Gold From Monsters (Based on Character Level)
Indestructible (zod)24% Chance to cast level 10 Weaken when struck+4 To All Skills+65% Faster Cast Rate+60% Faster Hit RecoveryKnockback (nef)+10 To Vitality (io)+10 To Energy (lum)Increase Maximum Life 15-25% (varies)Regenerate Mana 15-30% (varies)All Resistances +60-70 (varies)75% Extra Gold from Monsters (lem)30% Better Chance of Getting Magic Items (ist)