List of all high runes
What are high runes
High runes are expensive and hard to find runes. You should put great care into using these runes to make sure you not waste it. These runes also have very powerful attributes, but are usually best used to create top tier runewords like Enigma. High runes are commonly used as a currency for high value items.
High runes are generally considered to start from Vex runes, because it's the first rune that cannot be found from the Hell difficulty Hellforge quest and thus rely on a lot of luck to be found from a monster or treasure drop.