A lo rune is a high tier rune that can be socketed into armor and weapons. You can cube 2 ohm runes and a diamond together to get a lo rune.
A lo rune requires level 59 to use.
weapon20% Deadly Strikearmor/helm+5% to Maximum Lightning Resistshield+5% to Maximum Lightning Resist
Horadric cube recipes with lo runes
transmute 2 lo runes and a flawless topaz to create a sur rune