Malice is a Diablo 2 Resurrected runeword created by combining ith + el + eth into a 3 socket melee weapon. It requires at least level 15 to equip.
Malice has minor damage modifiers and the only real benefit of the weapon is the guaranteed Open Wounds and Prevent Monster Heal. This makes it a viable switch weapon for Bosses in Normal difficulty.
The Drain Life can take quite a toll over time if it is not balanced out by Life Generation or a Prayer Aura. Drain Life is the opposite of Replenish Life, the effect from Malice results in approximately -1 life every 2 seconds. Drain Life can not kill you (like poison).
Did you know? It takes on average 8 countess runs on Normal difficulty to get this runeword.