What runes make Sanctuary?

You need Ko + Ko + Mal rune to create Sanctuary.

Is Sanctuary ladder only?

No, Sanctuary is not ladder only.

Sanctuary runeword

Sanctuary is a Diablo 2 Resurrected runeword created by combining ko + ko + mal into a 3 socket shield. It requires at least level 49 to equip.

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Sanctuary increases your Hit Recovery Speed by 20%. Faster hit recovery reduces the "hit stun" animation time, which is triggered when a hit takes more than 1/12th of your total life.

faster hit recovery breakpoints
	faster hit recovery frames
	15	14	13	12	11	10	9	8	7	6	5	4	3
paladin							0	7	15	27	48	86	200
assassin							0	7	15	27	48	86	200
barbarian							0	7	15	27	48	86	200
amazon					0	6	13	20	32	52	86	174	600
necromancer			0	5	10	16	26	39	56	86	152	377
druid			0	5	10	16	26	39	56	86	152	377
sorceress	0	5	9	14	20	30	42	60	86	142	280
desert mercenary	0	5	9	14	20	30	42	60	86	142	280

Sanctuary also increases your Block Rate by 20%. An increased block rate will reduce the time it takes for the blocking animation to finish. Most classes will hit the first or second breakpoint with this shield.

faster block rate breakpoints
	faster block rate frames
	11	10	9	8	7	6	5	4	3	2	1
amazon							0	13	32	86	600
assassin							0	13	32	86	600
paladin							0	13	32	86	600
barbarian					0	9	20	42	86	280
sorceress			0	7	15	27	48	86	200
druid	0	6	13	20	32	52	86	174	600
necromancer	0	6	13	20	32	52	86	174	600