Plague runeword

Plague is a Diablo 2 Resurrected runeword created by combining cham + shael + um into a 3 socket sword, claw or dagger. It requires at least level 67 to equip.

The Plague runeword is a high level weapon runeword released in patch 2.4. It is one of the runewords that were in the original game files, but were disabled. Blizzard had announced 10 new runewords for patch 1.11, but only 7 made it in the final release (excluding Plague).

The allowed gear initially changed from all weapons to Swords only, this severely limited the usability and was a missed opportunity to give a solid runeword for Claws and Daggers.

Cleansing level breakdown
Cleansing level
duration reduction %727375767678787979

Plague has a 20% chance to cast a level 12 Lower Resist when struck.

Lower Resist level breakdown
Lower Resist level
duration (s)343638404244464850
resist all -%525455565758596061




Phase Blade'ChamShaelUm'required level: 67item type: Sword | Knife | Hand to Hand
  • 25% Chance to Cast Level 15 Poison Nova On Striking
  • 20% Chance to Cast Level 12 Lower Resist When Struck
  • Level 13-17 Cleansing Aura When Equipped (varies)
  • +1-2 All Skills
  • +20% Increased Attack Speed
  • +220-320% Enhanced Damage (varies)
  • -23% To Enemy Poison Resistance
  • 0.3% (0-29.7) Deadly Strike (Based on Character Level)
  • 25% Chance of Open Wounds
  • Freezes Target +3
  • socketed (3)

Eligible bases



Throwing Knife

Hand to Hand

Frequently asked questions

What runes make Plague?

You need Cham + Shael + Um rune to create Plague.

Is Plague ladder only?

No, Plague is not ladder only in Diablo 2 Resurrected.